The next generations of nuclear fusion reactors, including ITER and DEMO, will consider several different cooling systems for heat dissipation, power generation and tritium breeding. This includes the water-cooled lithium-lead blanket (WCLL) design, which bears significant similarities to the water-cooled circuit in a pressurised water fission reactor. Preparatory work has begun to analyse how the water chemistry regimes used in light water reactors might be adapted to a fusion cooling system. Mitigation procedures from LWRs such as hydrogen water chemistry, zinc and noble metal addition may prove useful in controlling the rate of corrosion in a WCLL circuit, a system which is also subject to aggressive radiolysis products of water and high flow velocities. In addition, a fusion cooling system must cope with several unique challenges, including higher neutron energies and fluxes, thermal excursions from plasma instability and strong magnetic fields up to 10T.