Piping systems that transport coolant and breeding fluid are naturally an essential part of the support system of the nuclear fusion power plants. Following a campaign of operations, the reactor is required to be shut down and maintained entirely. Pipes connected to the reactor components are to be cut, re-welded or re-joined, and inspected non-destructively, using Remote Handling (RH) equipment and tools. This paper outlines the candidate structural materials and their weldability in fusion reactor pipework, reviews investigated welding, cutting and NDE technologies, developed tooling prototypes and processes for remote pipe maintenance, summarizes the existing and emerging technological challenges that to be tackled as the results of the environmental constraints, material selections and the requirement of engineering designs, and highlights the exploration of the unknown and areas to further research in the future. The urge of developing tools with RH compatibility and high tolerance to environmental constraints, such as in-pipe robotics with miniaturized end effectors and sensors for operations and inspections under hazardous condition, is also addressed.