Solid titanium beryllide blocks will be used for neutron multiplication in the in the helium-cooled pebble bed (HCPB) blanket concept of EU DEMO. A combination of hot extrusion of Be-Ti powders and subsequent hot isostatic pressing (HIP) of the obtained Be-Ti composites has been proposed for manufacturing such blocks. This work is devoted to the study of the effect of HIP at 1000–1200°C on the structure and properties of Be-Ti composites in order to optimize the HIP parameters. The HIP at 1000–1200°С resulted in an almost single-phase titanium beryllide (TiBe₁₂) with small amounts of Be and other phases, which gradually dissolve with HIP temperature increase. Such a treatment at 1000 and 1100°C provides a very fine-grained microstructure of TiBe₁₂ with an average grain size of 0.3 and 0.6 μm, respectively. The resulting titanium beryllide is characterized by high microhardness of 1350–1480 HV_0.1 depending on the HIP temperature. According to the nanoindentation tests of the Be-Ti composite after HIP at 1100°C, the elastic modulus of TiBe₁₂ can be estimated as 295 GPa. The fracture toughness of the TiBe₁₂ was determined as 1.5–1.7 MPa·m^1/2. The temperature of 1100°C was chosen as optimal for the HIP of Be-Ti composites after hot extrusion. The titanium beryllide obtained in this way was used to manufacture a reduced size mockup of Ø20 mm×18 mm. The mockup has no visible surface defects and can be used for further experiments.