By mixing elements with favourable nuclear activation properties to create high-entropy alloys, it may be possible to create a material that can withstand a nuclear fusion environment while minimising the radioactive waste produced. Such a material could be used in the extreme thermal and irradiation conditions of a fusion blanket. A suite of previously unexplored V-Cr-Mn and V-Cr-Mn-Ti alloys have been fabricated then homogenised and the resultant microstructures and phases were characterised. Results demonstrate that single-phase body centred cubic solid solution microstructures can be formed in highly-concentrated alloys incorporating low-activation elements, which is promising for a fusion alloy development standpoint.